1. 个人信息 (Personals)
陈林，1982.11，教授，黄河科技科学院纳米功能材料研究所所长助理，河南省食药两用植物资源综合利用工程技术研究中心主任，河南省药用资源化学与生物学工程研究中心主任，硕士生导师。
中国菌物学会药用真菌专业委员会副主任委员，
中国菌物学会菌物化学专业委员会委员，
Email：lchenchina@163.com
2. 受教育经历 (Educational Experience)
2003年09月-2007年07月 河南大学药学院，理学学士
2007年09月-2010年07月 河南大学药学院，中药学硕士
2010年9月-2013年07月 清华大学医学部&北京协和医学院，生药学博士
3. 工作经历(Professional Experience)
2013年08月-至今 黄河科技学院
2017年02月-2019年02月 中国科学院微生物研究所，生物学博士后
4. 研究兴趣（Research Interests）
（1）活性天然产物发现：从植物和微生物中发现具有显著生物活性的化学成分。
（2）食药两用资源应用研究：开发食药两用资源相关食品和保健品
（3）蛋白质纯化工艺工开发：开发具有应用价值的高纯度天然蛋白和重组蛋白纯化工艺
（4）诊断试剂原材料研发：研究开发医学诊断试剂相关原材料
5.承担项目情况(Financial Supports)
[1] 2015年国家自然科学基金青年基金，养殖大黄鱼内生菌芽孢乳酸菌中抑菌先导化合物的发掘,项目编号：31501552，主持。
[2] 2019年度河南省科技攻关项目，狭旋毛壳中抗糖尿病先导化合物的发掘，192102310150，主持。
[3] 2021年度河南省科技攻关项目，狭旋毛壳中抗结肠癌先导化合物的发现及生物合成机制研究，
222102310518，主持。
[4] 2023年度河南省重点学科，生药学，Jiao Yan [2023] No. 235，学科方向带头人。
6. 代表性论著(Publications)
发表文章：
[1] Liwen Zhong, Peng Sun, Kaipeng Liu, Yuting Zhang, Kun Li, Jialu Chen, Lin Chen,* et al. Rehmannins A−D, anti-inflammatory carotenoid pigments from the fresh root of Rehmannia glutinosa [J].Organic Letters, 2026, 28: 1153-1158
[2] Huiqi Fang, Qi Li, Lin Chen*, Gang Ding*. Cochlioquinones 1968–2024: chemistry, biosynthesis, and biological activities with future perspectives [J]. Journal of Fungi, 2025, 11(10): 712
[3] Lin Chen, Ziying Yan, Bolei Yang, Bowen Tai, Weizhao Li, Erfeng Li*, Gang Wang*, Fuguo Xing. Differential retention and loss of a mycotoxin in fungal evolution [J]. Toxins, 2025, 17(311): 1-13
[4] Xiangyu Tan, Lin Chen (co-first author), Ying Chen, Yuxin Li, Lihan Lu, Erfeng Li*. The small GTPases FoRab5, FoRab7, and FoRab8 regulate vesicle transport to modulate vegetative development and pathogenicity in Fusarium oxysporum f. sp. Conglutinans [J]. Frontiers in Microbiology, 2025, (10.3389/fmicb.2025.1514092)
[5] Qingfeng Guo, Jinhai Luo, Xia Zhang, Jiale Zhi, Zhenhua Yin, Juanjuan Zhang, Baojun Xu*, Lin Chen*. A comprehensive review of the chemical constituents and functional properties of adzuki beans (Vigna angulariz) [J]. Journal of Agricultural and Food Chemistry, 2025 (on line)
[6] Zhenhua Yin, Juanjuan Zhang, Qingfeng Guo, Jiale Zhi, Xia Zhang, Wei Zhang, Lin Chen*. Characteristics of polysacchadride from Psoralea corylifolia in simulated gastrointestinal digestion and microbial fermentation [J]. Journal of Functional Foods, 2024, 122: 106549
[7] Yue Tan, Lin Chen (co-first author), Gang Ding. Naturally occurring asterric acid analogs: chemistry and biology [J]. Journal of Agricultural and Food Chemistry, 2024 (on line)
[8] Jiao Yu, Xinyang Wang, Man Liu, Jiale Zhi, Dandan Li, Juanjuan Zhang, Zhenhua Yin, Qingfeng Guo, Baocheng Yang, Lin Chen*. Chemical compositions of seeds from Chionanthus retusus [J]. Chemistry of Natural Compounds, 2024, 60(4): 723-725.
[9] Zhenhua Yin, Juanjuan Zhang, Jingjing Qin, Lin Guo, Qingfeng Guo, Wenyi Kang, Changyang Ma, Lin Chen*. Anti-inflammatory properties of polysaccharides from edible fungi on health-promotion: a review [J]. Frontiers in Pharmacology, 2024 (DOI 10.3389/fphar.2024.1447677).
[10] Qingfeng Guo, Shenyu Shen, Xinyang Wang, Lei Shi, Yuwei Ren, Dandan Li, Zhenhua Yin, Juanjuan Zhang, Baocheng Yang, Xuewei Wang, Gang Ding*, Lin Chen*. Bioactive cytochalasans from a desert soil-derived fungus Chaetomium madrasense 375 based on chemically engineered strategy [J]. Frontiers in Microbiology, 2024 (on line).
[11] Lei Shi, Dandan Li, Jiqian Guo, Jiale Zhi, Xinyang Wang, Juan-juan Zhang, Qingfeng Guo, Baocheng Yang, Lin Chen*. Secondary metabolites of Chaetomium angustispirale[J]. Chemistry of Natural Compounds, 2024, 60(3): 489-491.
[12] Qingfeng Guo, Lei Shi, Xinyang Wang, Dandan Li, Zhenhua Yin, Juanjuan Zhang, Gang Ding*, Lin Chen* . Structures and biological activities of secondary metabolites from the Trichoderma genus (Covering 2018–2022) [J]. Journal of Agricultural and Food Chemistry, 2023, 71(37): 13612-13632.
[13] Ying Liang, Ligong Hou, Guangjun Hou, Xianwei, Zhang, Lin Chen*, et al. The influences of the COVID-19 pandemic on Epstein-Barr virus infection in children, Henan, China [J]. Journal of Infrection, 2023 (on line).
[14] Jinhua Chen, Qingfeng Guo, Qiuge Liu, Baoxia He, Wenping Song, Zhenhua Yin, Dongbei Li, Lin Chen*, et al. Chaetoglobosin E inhibits tumor growth and promotes the anti-tumor efficacy of cytotoxic drugs in esophageal squamous cell carcinoma by targeting PLK1[J]. Annals of Translational Medicine, 2022, 10(22): 1236.
[15] Lin Chen, et al. The secondary metabolites and biosynthetic diversity from Aspergillus ochraceus[J]. Frontiers in chemistry, 2022 (doi: 10.3389/fchem.2022.938626).
[16] Qingfeng Guo, Jinhua Chen, Zhenhua Yin, Juanjuan Zhang, Jing Zeng, Baocheng Yang, Lin Chen*. Secondary metabolites of desert soil-derived fungus Chaetomium madrasense 375[J]. Chemistry of Natural Compounds, 2022, 58(3): 534-537.
[17] Zhenhua Yin, Juanjuan Zhang, Qingfeng Guo, Kai Sun, Lin Chen*. Two novel heteroglycan with coagulant activity from flowers of Cercis chinensis Bunge [J]. Journal of Molecular Structure, 2021, 1243: 130756.
[18] Qingfeng Guo, Jinhua Chen, Yuwei Ren, Zhenhua Yin, Juanjuan Zhang, Baocheng Yang, Xuewei Wang, Wenbing Yin, Wancun Zhang, Gang Ding, Lin Chen*. Hydrazine-containing heterocycle cytochalasans derivatives from hydrazinolysis of extracts of a desert soil-derived fungus Chaetomium madrasense[J]. Frontiers in Chemistry, 2021(doi: 10.3389/fchem.2021.
620589)
[19] Jinhua Chen, Qingfeng Guo, Jinxiang Zhang, Zhenhua Yin, Wenping Song, Baoxia He, Yongna Zhang, Wenzhou Zhang, Lin Chen*. Chaetoglobosin G inhibits proliferation, autophagy and cell cycle of lung cancer cells through EGFR/MEK/ERK signaling pathway [J]. Pharmazie, 2020, 72: 642-645.
[20] Wancun Zhang,Kangbo Liu, Pin Zhang, Weyland Cheng, Yaodong, Zhang, Linfei Li, Zhi danYu, Mengmeng Chen, Lin Chen*, et al. All-in-one approaches for rapid and highly specific quantifcation of single nucleotide polymorphisms based on ligase detection reaction using molecular beacons as turn-on probes [J]. Talanta, 2020: 121717.
[21] Lin Chen, et al. Diagnostically analyzing 1H NMR spectra of sub-types in chaetoglobosins for dereplication [J]. RSC advances, 2020, 10: 1946-1955.
[22] Qingfeng Guo, Zhenhua Yin, Juanjuan Zhang, Wenyi Kang, Xuewei Wang, Gang Ding and Lin Chen*. Chaetomadrasins A and B, two new cytotoxic cytochalasans from desert soil-derived fungus Chaetomium madrasense 375 [J]. Molecules, 2019, 24: 3240
[23] Lin Chen, et al. Genetic dereplication of Trichoderma hypoxylon reveals two novel polycyclic lactones [J]. Bioorganic Chemistry, 2019, 91: 103185
[24] Lin Chen, et al. Metabolomic comparison between wild Ophiocordyceps Sinensis and artificial cultured Cordyceps militaris [J]. Biomedical Chromatography, 2018, 32(2): 4279
[25] Lin Chen, et al. Trichodermatides E and F from fungus Trichoderma applanatum [J]. Journal of Asian Natural Products Research, 2018, 23: 1-7
[26] Lin Chen, et al.Chemical constituents of Bacillus coagulans LL1103 [J]. Chemistry of Natural Compounds, 2018, 54: 419-420
[27] Lin Chen, et al. Trichoderpyrone, a unique polyketide hybrid with a cyclopentenone-pyrone skeleton from the plant endophytic fungus Trichoderma gamsii [J]. Journal of Natural Products, 2017, 80: 1944-1947
[28] Gang Ding, Lin Chen (co-first author), et al. Trichoderamides A and B, a pair of stereo- isomers from the plant endophytic fungus Trichoderma gamsii [J]. The Journal of Antibiotics, 2015, 68: 409-413
[29] Lin Chen, et al. Stereochemical determination of new cytochalasans from the plant endophytic fungus Trichoderma gamsii [J]. Fitoterapia, 2014, 96: 115-122
[30] Lin Chen, et al. Two new derivatives of 2, 5-dihydroxyphenyl acetic acid from the kernel of Entada phaseoloides [J]. Molecules, 2013, 18: 1477-1482
[31] Gang Ding, Lin Chen, et al. Trichalasins C and D from the plant endophytic fungus Trichoderma gamsii [J]. Fitoterapia, 2012, 83: 541-544
授权发明专利：
[1] 陈林等，可皆霉素在制备治疗糖尿病药物中的应用，2017，CN105232541B
[2] 陈林等，一种从凝结芽孢杆菌中提取环(甘-丙)二肽的方法，2018，CN105624244B
[3] 陈林等，一种从凝结芽孢杆菌中提取环(脯-甘)二肽的方法，2018，CN105695544B
[4] 陈林等，一种从凝结芽孢杆菌中提取环(甘-酪)二肽的方法，2018，CN105648002B
[5] 陈林等，一种制备可皆霉素的方法，2019，CN105296566B
[6] 陈林等，可皆霉素在制备抗炎药物中的应用，2019，CN106377525B
[7] 陈林等，可皆霉素在制备治疗糖尿病药物中的应用，2019，CN106176719B
[8] 陈林等，一种利用狭旋毛壳菌发酵生产可皆霉素的方法，2020，CN106834375B
[9] 陈林等，一株伊比利亚单孢囊菌及其应用，2021，CN112195106B
[10] 陈林等，可皆霉素在制备抗肿瘤药物中的应用，2024，CN114869882B
参编书籍：
【1】《天然有机化合物核磁共振碳谱》，参编，2011，ISBN 9787122126955，化学工业出版社。
7. 荣誉（Honors）
(1) 2007年获河南大学优秀毕业生
(2) 2010年获河南大学侯镜如奖学金
(3) 2016年获黄河科技学院“先进工作者”
(4) 2019年获河南省科学技术成果二等奖
(5) 2020年获河南省本科教育线上教学优秀课程一等奖
(6) 2020年获黄河科技学院“文明教工”
(7) 2021年获黄河科技学院“优秀教育工作者”
(8) 2021年获黄河科技学院“先进工作者”
(9) 2021年获中国商业联合会科学技术奖一等奖
(10) 2022年获郑州市二七区最美科技工作者
(11) 2023年获中国商业联合会科学技术奖二等奖
(12) 2023年获河南省“互联网+”大学生创新创业大赛三等奖（指导老师）
(13) 2023年获黄河科技学院“优秀教育工作者”
(14) 2024年获河南省医学会河南医学科技奖二等奖
(15) 2024年获河南省教育厅科技成果一等奖
(16) 2025年获中国国际大学生创新大赛河南赛区选拔赛二等奖（指导老师）