1.个人信息（Personals）
女，1988.6.23，博士，硕士生导师，Email：10200113@vip.henu.edu.cn
2.受教育经历 (Educational Experience)
2014/09 - 2017/07，中国科学院昆明植物研究所，博士
2011/09 - 2014/07，中国科学院昆明植物研究所，硕士
2007/09 - 2011/07，河南大学，学士
3.工作经历(Professional Experience)
2021/06-至今，河南大学，副教授
2017/09-2021/05，河南大学，讲师
4.研究兴趣（Research Interests）
（1）天然产物活性成分研究：以活性为导向的天然产物分离、结构鉴定，涉及“谱效关系-敲出技术-高分辨质谱技术”快速发现复杂中药体系中的活性成分。
（2）药理活性研究：活性成分的抗糖尿病、凝血、抗炎、免疫等活性的研究。
5.承担项目情况(Financial Supports)（包括项目名称，批准号，金额，起止年月，基金来源，本人角色）
[1] 黄花败酱改善3T3-L1脂肪细胞胰岛素抵抗的活性成分及作用机制研究，31900292，23万，2020.01-2022.12，国家自然科学基金青年基金，主持.
[2] 基于“网络药理学-代谢组学-蛋白质组学”技术的黄花败酱降血糖机制研究，222102520035，立项，2022.01-2023.12，河南省科技厅科技攻关项目，主持.
[3] 黄花败酱活性成分多靶点改善2型糖尿病作用研究，立项，212102110469，立项，2021.01-2022.12，河南省科技厅科技攻关项目，主持
[4] 环烯醚萜类化合物改善胰岛素抵抗作用及机制研究，202102110149，立项，2019.12-2021.12，河南省科技攻关计划项目，主持.
[5] 黄花败酱降血糖功能研究，192102110112，立项，2019.01-2020.12，河南省科技发展计划项目，主持.
[6] 药食两用资源黄花败酱降血糖活性成分及作用机制研究，1908005，5万元，2018.07-2020.07，开封市科技局，主持.
[7] 典型天然植物化合物绿色制造关键技术研究，2022YFF1100300，2000万元，2022.12-2026.12，国家重点研发计划，参加.
[8] 食用菌资源开发和高效加工关键技术研究，2018YFD0400202，52万元，2019.01-2021.12，科技部国家重点研发，参加.
[9] 基于质谱分子网络从近缘亚属发现重楼药材可替代资源的评价研究，31770391，60万元，2018.01-2021.12，国家自然科学基金面上项目，参加.
6.代表性论著(Publications)
期刊论文(Journal Articles)
1. Zhenhua-Liu, Mengke-Wang, Lijun-Meng, Yixiao-Chen, Qiuyi-Wang, Yan-Zhang*, Xuefeng-Xi*, Wenyi-Kang*. Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression. Food Science and Human Wellness, 2023, 12: 2014-2021. SCI 1区Top.
2. Senye-Wang, Li-Zhou, Fatma Al-Zahra K K Attia, Qi-Tang, Mengke-Wang, Zhenhua-Liu*, Geoffrey I N Waterhouse*, Lijun Liu*, Wenyi Kang*. Origanum majorana L.: a nutritional supplement with immunomodulatory effects. Frontiers in Nutrition, 2021,8(2021): 748031-748041. SCI 1区Top.
3. Yun-Niu, Baoguang-Wang, Li-Zhou, Changyang-Ma, Geoffrey I N Waterhouse, Zhenhua-Liu*, Adel F Ahmed*, Dongxiao Sun-Waterhouse*, Wenyi-Kang*. Nigella sativa: a dietary supplement as an immune-modulator on the basis of bioactive components. Frontiers in Nutrition, 2021,8(2021): 722813-722823. SCI 1区Top.
4. Cunyu-Liu, Changyang-Ma, Jie-Lu, Lili-Cui, Mengzhu-Li, Ting-Huang, Yunhui-Han, Yong-Li, Zhenhua-Liu*, Yan-Zhang*, Wenyi-Kang*. A rapid method and mechanism to identify the active compounds in Malus micromalus Makino fruit with spectrum-effect relationship, components knock-out and molecular docking technology. Food and Chemical Toxicology, 2021,150(2021): 112086-112099. SCI 2区Top.
5. Xiaoqing-Xu, Pengyu-Wang, Baoguang-Wang, Mengke-Wang, Senye-Wang, Zhenhua-Liu*, Yan-Zhang*, Wenyi-Kang*. Glucose absorption regulation and mechanism of the compounds in Lilium lancifolium Thunb on Caco-2 cells. Food and Chemical Toxicology, 2021,149(2021): 112010-112017. SCI 2区Top.
6. Meng-Jun Shi, Yi-Ping Cui, Cun-Yu Liu, Chang-Qin Li, Zhen-Hua Liu*, Wen-Yi Kang*. CYPs-mediated drug-drug interactions on psoralidin, isobavachalcone, neobavaisoflavone and daidzein in rats liver microsomes. Food and Chemical Toxicology, 2020, 136 (2020): 111027-111035. SCI 2区Top.
7. Zhenhua-Liu, Lanting-Xu, Xiaoqing-Xu, Yun-Niu, FatmaS A Saadeldeen, Wenyi-Kang*. Effects and mechanisms of iridoid glycosides from Patrinia scabiosaefolia on improving insulin resistance in 3T3-L1 adipocytes. Food and Chemical Toxicology, 2019, 134(2019), 110806-110832. SCI 2区Top.
8. Wenjing-Li, Yan-Zhang, Shujin-Shi, Gen-Yang, Zhenhua-Liu*, Jinmei-Wang*, Wenyi-Kang*. Spectrum-effect relationship of antioxidant and tyrosinase activity with Malus pumila flowers by UPLC-MS/MS and component knock-out method. Food and Chemical Toxicology, 2019, 133(2019), 110754-110771. SCI 2区Top.
9. Zhenhua-Liu, Lanting-Xu, Meimei-Xing, Xiaojie-Xu, Jinfeng-Wei, Jinmei-Wang*, Wenyi-Kang*. Trelagliptin succinate: DPP-4 inhibitor to improve insulin resistance in adipocytes. Biomedicine & Pharmacotherapy, 2020, 125（2020）:109952-109957. SCI 2区TOP.
10. Zhenhua-Liu, Mengke-Wang, Yuhang-Liu, Mengjie-Ren, Xuefeng-Xi*, Shiming-Li*, Wenyi-Kang*. Patrinoside and patrinoside A from Patrinia scabiosaefolia improve insulin resistance by inhibiting NF-κB, MAPK pathways and oxidative stress in RAW264.7 and 3T3-L1 Cells. Oxidative Medicine and Cellular Longevity, 2023, 2023: 9069645. SCI 2区.
11. Zhenhua-Liu, Yun-Niu, Li-Zhou, Lijun-Meng, Sitan-Chen, Mengke-Wang, Jiangmiao-Hu*, Wenyi-Kang*. Nine unique iridoids and iridoid glycosides from Patrinia scabiosaefolia. Frontiers in Chemistry, 2021, 9 (2021): 657028-657041. SCI 2区.
12. Changqin-Li, Yiping-Cui, Jie-Lu, Lijun-Meng, Changyang-Ma, Zhenhua-Liu*, Yan-Zhang*, Wenyi-Kang*. Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method. Food Science and Human Wellness, 2021,10(2021),278-288. SCI 2区.
13. Yingying-Niu, Jing-Dong, Huimin-Jiang, Jinmei-Wang, Zhenhua-Liu*, Changyang-Ma*, Wenyi-Kang*. Effects of polysaccharide from Malus halliana Koehne flowers in cyclophosphamide-induced immunosuppression and oxidative stress on mice. Oxidative Medicine and Cellular Longevity, 2020, 2020 (2020): 1603735-1603744. SCI 2区.
14. Fatma S.A. Saadeldeen, Yun-Niu, Honglin-Wang, Li-Zhou, Lijun-Meng, Sitan-Chen, Dongxiao Sun-Waterhouse, Geoffrey Ivan Neil Waterhouse, Zhenhua-Liu*, Wenyi-Kang*. Natural products: regulating glucose metabolism and improving insulin resistance. Food Science and Human Wellness 2020, 9 (2020): 214-228. SCI 2区.
15. Xuqiang-Liu, Nan-Jiang, Xiaoqing-Xu, Cunyu-Liu, Zhenhua-Liu*, Yan-Zhang*, Wenyi-Kang*. Anti-hepatoma compound determination by the method of spectrum effect relationship, component knock-out, and UPLC-MS2 in Scheflera heptaphylla (L.) Frodin Harms and its mechanism. Frontiers in Pharmacology, 2020, 11 (2020): 1342-1354. SCI 2区.
16. Lili-Cui, Jinmei-Wang, Mengke-Wang, Baoguang-Wang, Zhenhua-Liu*, Jinfeng-Wei*, Wenyi-Kang*. Chemical composition and glucose uptake effect on 3T3-L1 adipocytes of Ligustrum lucidum Ait. flowers. Food Science and Human Wellness, 2020, 9(2020): 124-129. SCI 2区.
17. Changqin-Li, Miyun-Hu, Shengjun-Jiang, Zhenhua-Liang, Jinmei-Wang, Zhenhua-Liu*, Hui-Min David Wang*, Wenyi-Kang*. Evaluation procoagulant activity and mechanism of astragalin. Molecules, 2020, 25(2020): 177-192. SCI 3区.
18. Changqin-Li, Yiping-Cui, Jie-Lu, Cunyu-Liu, Sitan-Chen, Changyang-Ma, Zhenhua-Liu*, Jinmei-Wang*, Wenyi-Kang*. Ionic liquid-based ultrasonic-assisted extraction coupled with hplc and artificial neural network analysis for Ganoderma lucidum. Molecules, 2020, 25(2020): 1309-1324. SCI 3区.
19. Xuqiang-Liu, Changyang-Ma, Zhenhua-Liu*, Wenyi-Kang*. Natural products: review for their effects of anti-HBV. BioMed Research International, 2020, 2020(2020): 1-24. SCI 3区.
20. Pengyu-Wang, Jian-Li, Fatma Alzahra K. Attia, Wenyi-Kang, Jinfeng-Wei, Zhenhua-Liu*, Changqin-Li*. A critical review on chemical constituents and pharmacological effects of Lilium. Food Science and Human Wellness, 2019, 8(2019)，330-336. SCI 2区.
21. Xuqiang-Liu, Jing-Dong, Qiongxin-Liang, Hui-min David Wang, Zhenhua-Liu*, Ruian-Xu*, Wenyi-Kang*. Coagulant effects and mechanism of Schefflera heptaphylla (L.) Frodin. Molecules, 2019, 24(2019): 4547-4549.SCI 3区.
22. Mengjun-Shi, Juanjuan-Zhang, Cunyu-Liu, Yiping-Cui, Changqin-Li, Zhenhua-Liu*, Wenyi-Kang*. Ionic liquid-based ultrasonic-assisted extraction to analyze seven compounds in Psoralea Fructus coupled with HPLC, Molecules, 2019, 24(2019): 1699-1713. SCI 3区.
23. Xiaoqing-Xu, Fatma S A Saadeldeen, Lanting-Xu, Yingying-Zhao, Jinfeng Wei, Hui-Min David Wang*, Zhenhua-Liu*, Wenyi-Kang*. The mechanism of phillyrin from the leaves of Forsythia suspensa for improving insulin resistance. BioMed Research International, 2019, 2019(2019): 3176483-3176489. SCI 3区.
24. Lili-Cui, Miyun-Hu, Pengran-Cao, Yun-Niu, Changqin-Li, Zhenhua-Liu*, Wenyi-Kang*. Chemical constituents and coagulation activity of Syringa oblata Lindl flowers. BMC Chemistry, 2019,13(2019): 108-115. SCI 3区.
25. Lili-Cui, Xingzi-Hou, Wenjing-Li, Yuchun-Leng, Yang-Zhang, Xinjuan-Li, Yangyang-Hou, Zhenhua-Liu*, Wenyi-Kang*. Dynamic changes of secondary metabolites and tyrosinase activity of Malus pumila flowers. BMC Chemistry, 2019,13(2019): 81-88. SCI 3区.
26. Zhen-Hua Liu, Bo Hou, Liu Yang, Rui-Jing Ma, Jin-Yu Li, Jiang-Miao Hu*, Jun Zhou*. Iridoids and bis-iridoids from Patrinia scabiosaefolia. RSC Advances, 2017, 7: 24940-24949. SCI 3区.
27. Zhen-Hua Liu, Rui-Jing Ma, Liu Yang, Jin-Yu Li, Jiang-Miao Hu, Jun Zhou. Triterpenoids and iridoids from Patrinia scabiosaefolia. Fitoterapia, 2017, 119: 130-135. SCI 3区.
28. Zhen-Hua Liu, Huan Yan, Yong-Ai Si, Wei Ni, Yu Chen, Li He, Hai-Yang Liu*. Bioactive spirostane glycosides from Tacca plantaginea. Steroids, 2016, 106: 86-92. SCI 3区.
29. Jie-Lu, Jing-Tian, Li-Zhou, Lijun-Meng, Sitan-Chen, Changyang-Ma, Jinmei-Wang, Zhenhua-Liu*, Changqin-Li*, Wenyi-Kang*. Phytochemistry and biological activities of Poria. Journal of Chemistry, 2021, 2021(2021): 1-20. SCI 4区.
30. Li-Zhou, Fatma Al-Zahra Kamal Kamel Attia, Lijun-Meng, Sitan-Chen, Zhenhua-Liu*, Changyang-Ma*, Lijun-Liu*, Wenyi-Kang*. Chemical components and biological effects of Genus Origanum. Journal of Food Quality, 2021: 1-19. SCI 4区.
31. Yun-Niu, Li-Zhou, Lijun-Meng, Sitan-Chen, Changyang-Ma*, Zhenhua-Liu*, Wenyi-Kang*. Recent Progress on chemical constituents and pharmacological effects of the Genus Nigella. Evidence-based Complementary and Alternative Medicine, 2020, 2020(2020): 6756835-6756849. SCI 4区.
32. Yun-Niu, Shengfeng-Wang, Changqin-Li, Jinmei-Wang, Zhenhua-Liu*, Wenyi-Kang*. Effective compounds from Caesalpinia sappan L. on the tyrosinase in vitro and in vivo. Natural Product Communications, 2020, 15(2020): SCI 4区.
33. Zhen-Hua Liu, Lan-Ting Xu, Xiao-Qing Xu, Yun Niu, Fatma S. A. Saadeldeen, Wen-Yi Kang*. Effects and mechanisms of iridoid glycosides from Patrinia scabiosaefolia on improving insulin resistance in 3T3-L1 adipocytes. Food and Chemical Toxicology, 2019, 134: 110806. SCI 4区.
7.奖励（Awards）
[1] 药食两用资源功效成分识别与质量控制关键技术，河南省科学技术进步奖二等奖，3，2021.02.10
[2] 保健食品功效识别与质量控制关键技术，河北省科学技术进步奖二等奖，5，2022.03.26
[3] 功能性食品资源综合挖掘与开发利用，河南省科学技术进步奖二等奖，5，2023.12.15
[4] 保健食品、化妆品及其原材料中植物功效成分识别、鉴定与检测技术研究，市场监管科研成果奖，8，2021.08.23
[5] 天然植物化学成分鉴定、功效识别及检测技术研究，中国商业联合会科学技术奖特等奖，7，2020.12
[6] “谱效关系”结合“敲除技术”快速确定功效成分及功能产品开发，中国商业联合会科学技术奖一等奖，7，2019.12